RESEARCH PROGRESS AND PROSPECTS OF INFORMATICS OF TRADITIONAL CHINESE MEDICINE


Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy.Spatial relationships among cells groovy mama ring including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity.Methods: We demonstrat

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential.Complex I from Escherichia coli is jumbo glory double wall 2li bardak 250 ml among the best functionally characterized complexes, but its structure remains unknow

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